Description
Unit: 1 Box (20 Tests)
Regulatory Status: Moderately Complex , Professional Use Only
Contents: (20) LifeSign MI® Troponin I Tests with dropper, Result stickers, Directions for use
Determinations: Cardiac troponin I (cTnI) in human whole blood, serum and plasma
Storage Requirements: 36° – 86° F
Processing Time: 15 Minutes
- MODERATELY COMPLEX
- Qualitative Troponin I
- Enables prompt emergency room decisions
- Easy to use procedure; Add 3 drops of specimen into device
- Read results in 15 minutes
- Improves patient care
- Reduces unnecessary testing and admissions
For the rapid qualitative detection of cardiac troponin I (cTnI) in human whole blood, serum and plasma as an aid in the diagnosis of myocardial infarction in emergency room, critical care, point-of-care, and hospital settings. The LifeSign MI® Troponin I Assay provides a qualitative analytical test result. The qualitative nature of this assay does not provide information about change- either the rise or fall – in the concentration of cTnI with single testing. A quantitative method should be used, if desired, to determine the concentration of cTnI at any given time. Only with serial testing could a temporal change in the level of cTnI be concluded. Clinical consideration and professional judgement should be applied when interpreting the results of the LifeSign MI® Troponin I Assay, especially when single testing results are used.
Summary and Explanation: The troponin complex is formed of three subunits, troponin T (TnT), troponin C (TnC) and Troponin I (TnI). The three troponin subunits have distinct functions with TnC as the Ca++-binding, TnT as the tropomyosin binding, and TnI as the inhibitory subunits.1 The troponin complex, together with tropomyosin, form the main component that regulates the Ca++-sensitive ATPase activity of actomyosin in striated muscle (skeletal and cardiac).2 Different isoforms of TnI exist in the skeletal and cardiac muscles (sTnI and cTnI, respectively) with distinct structural heterogeneity between these isoforms that allow the production of isoform-specific antibodies.3 These isoform-specific antibodies have been utilized to assemble various detection methods that are isoform-specific. Recent reports have investigated the utility of determining the serum levels of the different isoforms of TnI.
